منابع مشابه
Relevance of genomics to healthcare and nursing practice.
Much has been learned over the past 10 years about the relevance of genomic variation to health, to the risk for both rare and common diseases, and to treatment responsiveness (Feero, Guttmacher, & Collins, 2010). The identification of genomic differences that play a role in disease provides information that is enhancing our understanding about the biology of disease, resulting in new and more ...
متن کاملSelenoproteins – biochemistry and clinical relevance
Klaus Schwarz (1914–1978), a pioneer of biomedical selenium research. Five decades ago, selenium had been recognized as an essential trace element for bacteria by Jane Pinsent and for higher vertebrates by Klaus Schwarz (see photo) and Calvin M. Foltz, who isolated a selenium-containing compound from hog kidney, the ‘factor 3’ that protected rats against dietary liver necrosis. Fifteen years la...
متن کاملCachexia: pathophysiology and clinical relevance.
Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess m...
متن کاملRelevance for clinical practice
OBJECTIVE To review evidence from literature on type 2 diabetes pertinent to physical activity and diet and lifestyle modification, and to determine the relevance of this evidence to clinical practice. QUALITY OF EVIDENCE Direct (level I) evidence supports interventions for physical activity and diet modification for primary prevention and management of type 2 diabetes. Few studies examine the ...
متن کاملClinical Relevance of Adipokines
The incidence of obesity has increased dramatically during recent decades. Obesity increases the risk for metabolic and cardiovascular diseases and may therefore contribute to premature death. With increasing fat mass, secretion of adipose tissue derived bioactive molecules (adipokines) changes towards a pro-inflammatory, diabetogenic and atherogenic pattern. Adipokines are involved in the regu...
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ژورنال
عنوان ژورنال: Science
سال: 2011
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1202572